suppression des mutations non-sens

Traductions

• anglais

  Auteur : Conseil de recherches médicales du Canada, 1986

  Définition

  Suppression of the polypeptide chain termination effect of a nonsense codon and partial or complete restoration of the normal phenotype.

  Note :

  In the case of nonsense suppression, nonsense codons can act as sense (amino acid specifying) codons. This may be due to the presence of a nonsense suppressor gene or a chemical suppressor gene or a chemical suppressor (such as 5-fluoro-uracil and streptomycin). If, for instance, the nonsense triplet is UAA, then the substitution of 5-fluoro-uracil (5-FU) for U in the mRNA may result in the reading of FUAA as CAA, a sense codon. This will allow translation to continue since the tRNA will mistake FU for C with a higher probability than if U were present. The efficiency of nonsense suppression depends on the balance between polypeptide chain termination and amino acid insertion and may be drastically affected by the composition of the nucleotides adjacent to the nonsense codon.

  Terme :

  1. nonsense suppression