vidarabine

Traductions

• anglais

  Auteur : Université du Québec à Trois-Rivières, 1988

  Définition

  An anti-viral agent.

  Note :

  Synthesized in 1960, it was subsequently found as a naturally occurring nucleoside in culture filtrates of streptomyces antibioticus. Mode of action unclear but it probably inhibits viral DNA polymerase. It neither directly inactivates virus nor prevents attachment. In the body it is speedily converted to the hypoxanthine, with a decline to less than 50% of the original anti-viral activity. It is active against herpesvirus and poxvirus; less so against adenovirus and papovavirus. With the exception oncovirus the drug has no action against RNA viruses. Studies of its effect in viral encephalitis suggest that useful blood levels can be obtained with doses small enough to avoid toxicity. In some patients tremors, nausea, vomiting and toxic encephalopathy have been reported, particularly at high doses. It may be given i/v but it is irritating on injection i/m. Also used as a 3% opthalmic ointment. It is teratogenic in rats and rabbits.

  Termes :

  1. adenine arabinoside
  2. ara-A
  3. vidarabin
  4. vidarabine